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Inhibiting intimal SMC-like cell proliferation has been used as a therapeutic strategy to antagonize pathologic vascular remodeling. Synthetic SMCs down-regulate contractile proteins and up-regulate growth factors, hiesbegrer factor receptors, extracellular matrix ECM components, ECM proteinases and inflammatory mediators 56. Importantly, different PDE isoforms serve to control distinct cyclic nucleotide signaling and fulfill distinct functions. Thus, selectively targeting individual PDE isoforms may represent a feasible and appealing strategy for modulating specific cyclic nucleotide pools without affecting global intracellular cyclic nucleotides.
Clinical psychology can address brief or acute personal issues to severe, chronic mental, emotional or physiological conditions. Why might I see a Psychologist? Where does a Psychologist work? However, these drugs also attenuate re-endothelization, and can lead to increased in-stent thrombosis 9. Psychologists can also work as researchers for universities and organizations. In addition, although DES is effective for focal lesions, DES cannot treat vascular disorders with diffuse neointimal lesions.