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The caffeine is therefore absorbed more quickly and Cotfee higher concentration than it is in when coffee is drunk. Benefits of Enemas and Colonics with Coffee Enemas and Colonics have been used for hundreds of years, and are generally regarded as safe. Additionally, Cooffee cleansing enemas have a chemical makeup that is stimulative. The enzymes in coffee, known as palmitates, help the liver carry away the toxins in bile acid. The coffee is absorbed into the hemorrhoidal vein, then taken up to the liver by the portal vein. With the bile ducts dilated, bile carries toxins away to the gastrointestinal tract. Simultaneously, peristaltic activity is encouraged because of the flooding of the lower colon.
Thus, when the colon is evacuated, the toxins and bile are carried out of the body. Enema and Colonic Supplies and kits You will need to buy a reusable enema kit. Enema products are available at most pharmacies. They are usually disposable although they can be cleaned and reused for several months and they are inexpensive. Organic coffee, any roasting level will do. Coffee Enema Recipe Bring 8 cups of water to a boil. Grind eight heaping tablespoons of organic coffee. Put it in a french press pot. You can use a drip coffee maker, but be sure to use organic, unbleached coffee filters.
Pour the water over the coffee grounds and let it steep then cool for one hour or more. After this anql of time, the liquid should be about body temperature. If you stick your finger in the water it should be lukewarm or cool, but not hot. Press the coffee grounds to the bottom, then pour the coffee liquid into the enema bag. Never utilize flavored coffee, sweetened coffee, or coffee with milk cafe au lait for this purpose.
The use of coffee in Coffee enema anal colonic, enema, or suppository will result in cleansing alongside anaal heightened sense of well being, pleasure, and a release of toxins. Blood samples were collected immediately before and at enemma time points until 12 hours after coffee administration in each phase. The mean caffeine content in both the coffee solution prepared for the coffee enema and the ready-to-drink coffee eenma was not statistically different. The and AUC of caffeine obtained from the coffee enema were about 3.
In summary, the relative dnema of caffeine obtained from the coffee enema was about 3. Hence, some traditional physicians recommend routine treatment by the enema, a procedure involving the infusion of water or other fluids into the colon through the anus, in order to shorten the contact time of the toxins in the colon [ 45 ]. Max Gerson OCffee it for the purpose of cancer therapy in the s. According to the Gerson regimen [ 56 ], caffeine from the coffee enema is believed to cause dialysis of toxic products from blood across the colonic walls or to cause dilation of the bile ducts, which in turn facilitates the process of elimination of toxic products from the liver.
Nonetheless, none of these claims regarding the production of substantial health benefits by coffee enema and other colonic cleansing treatments has been supported by scientific research [ 7 — 9 ]. Although the evidence for health benefits is lacking, the usage of coffee enema is still very popular among patients in Thailand, especially in the treatment of cancers, allergies, asthma, urticaria, migraine, dyslipidemia, obesity and chronic constipation, and so forth. The documented potential risks of coffee enema include rectal burn induced by hot enema fluid [ 1011 ], proctocolitis [ 1213 ], polymicrobial enteric septicemia [ 14 ], electrolyte imbalance, or even death [ 15 ].
In addition, systemic adverse effects from colonic absorption of caffeine following a coffee enema are another issue that might be of concern to enema users or even mainstream physicians. In fact, several lines of evidence suggest that caffeine can be absorbed via the rectum or colon into systemic circulation as it has been used as a test drug in the evaluation of pressure-controlled colon delivery capsules PCDCs [ 16 ]. Furthermore, caffeine can be used in combination with ergotamine in rectal suppository dosage form in order to enhance the vasoconstrictive effect of ergotamine in the treatment of migraine headache [ 17 ].
However, the colonic absorption of caffeine following coffee enema considerably differs from that following administration of a PCDC or a rectal suppository because the coffee enema procedure usually involves administration of a larger volume of warm and diluted coffee solution about mL into the rectum and colon through the anus.
During the wealth phase, traps had to be paramount to retain the water hookup for at least 10 min. Hockey Sample Collection for Forgiveness of Information Pharmacokinetic Boundaries In each model phase, camps were disbanded overnight for at least 8 h. The banners of sun a huge enema are not the same as being coffee.
Additionally, the subject oCffee normally requested to retain the coffee enema fluid for a short period of time about 10—15 min before defecation, leading to limitation of Coffee enema anal of caffeine absorption. Based on this, it is hypothesized that the extent of caffeine absorption should be rather low, especially in relation to that following an amal of PCDC, rectal formulation, or even oral coffee consumption. Despite this, no scientific research regarding caffeine pharmacokinetics following coffee enema has yet been reported. The primary objective of this study was therefore to compare the pharmacokinetic parameters of caffeine after a single dose of the coffee enema with those of coffee which was consumed orally in healthy male subjects.
The secondary objective was to evaluate the safety profile of a single administration of these coffee procedures on blood pressure and heart rate. Materials and Methods 2. Study Design The present study was a substudy related to the investigation which has been reported elsewhere by Teekachunhatean et al. This study was an open-label, randomized two-phase crossover study.
Eleven healthy subjects were randomly assigned to receive either mL of coffee enema for 10 minutes or to consume mL of coffee beverage. After a washout period of at least 10 days, all subjects were switched to receive the alternate coffee procedure. Subjects were randomized by a computer-generated list. The allocation sequence was implemented through placing the allocation cards in opaque, sealed, and stapled envelopes to preserve concealment. The envelopes were numbered in advance and opened sequentially only after the enrolled subjects completed all baseline assessments, and it was time to allocate which coffee procedure should be administered first in a given sequence.
Subjects A total of 11 healthy men, aged 18—25 years ywere enrolled in this study. All had to be in good health on the basis of medical history and a physical examination. Routine blood tests including a complete blood count, a liver function test and a measurement of blood urea nitrogen and creatinine levels were used to screen subjects in order to exclude those with abnormal hematological diseases or abnormal liver or kidney functions. All subjects had to have normal blood pressure and heart rate. During the screening phase, subjects had to be able to retain the water enema for at least 10 min. Subjects included in the study were given thorough verbal and written information regarding the nature of the study.
Signed informed consent of each subject was obtained prior to the study. Other exclusion criteria were chronic renal, liver, neurological, pulmonary, or cardiovascular diseases, recent cigarette smoking within the previous 3 months, a history of substance abuse or addiction, the use of any medication within the previous month, and hypersensitivity to medications in the xanthine group such as theophylline or aminophylline. Withdrawal criteria of this study were those subjects who experienced adverse drug reactions during the study, subjects who could not comply with the study protocol or those who wished to voluntarily withdraw from the study, and any subject who required other medication during the study period.
Coffee Enema and Coffee Enema Procedure The coffee solution used in the enema procedure was prepared by mixing 4 g of finely ground coffee beans VS coffee, manufactured by V. The coffee enema devices used in this study were the disposable commercial set Cleansing Enema set, made in Mexico, imported by Thanyaphu Co. The nozzle was lubricated with 2 drops of organic olive oil and then inserted 2 inches into the anus while the subject was lying down on his left side, with his legs curled into the abdomen. The bed height was 3 feet above the floor, whereas the enema bag was hung 5 feet above the floor. The coffee solution in the enema bag was completely infused within 5—10 min.
The subject was requested to retain the coffee enema fluid for 10 min. During this period, the subject was instructed to change his lying position to the right side for 3. Oral Coffee Consumption The coffee used for oral consumption in this study was the commercially available ready-to-drink coffee beverage instant coffee with milk and sugarRed Bull Coffee manufactured by TC Pharmaceutical Industry Co. The net volume of 1 serving was mL. Each subject was instructed to consume the entire coffee serving within 1 min followed by mL of water. They were randomly assigned to receive either the coffee enema or to orally consume the coffee beverage.
Blood samples were collected at different specific time points see below. After blood sample collection 12 hours h after dose, the subjects were discharged from the Clinical Pharmacology Unit. After a washout period of at least 10 days, subjects were switched to the second phase receiving the alternate coffee preparation, and the blood samples were collected in the same manner. Identical meals and fluids were served during the 2 study phases. All subjects were required to refrain from drinking beverages containing caffeine except those given in this study and alcohol from the time of screening until the end of the research study.
After initiating each coffee procedure, subjects continued fasting until water and lunch were served 2 h and 6 h afterwards, respectively. Blood Sample Collection for Determination of Caffeine Pharmacokinetic Parameters In each study phase, subjects were fasted overnight for at least 8 h. Venous blood samples were taken via heparinized IV catheter inserted into a forearm vein. Fifteen mL of blood samples were drawn from each subject prior to an administration of either the coffee enema or oral coffee consumption and again 10, 20, 30, 40, and 60 min and 1.
Determination of Caffeine Concentrations in Coffee Solutions The assay of caffeine content was modified from the high-performance liquid chromatography HPLC method and conditions previously reported elsewhere [ 1819 ]. The chromatography condition consisted of two mobile phases. Determination of Caffeine Concentrations in Plasma The assay was modified from the protein precipitation procedure previously described elsewhere [ 1820 ]. After vortex mixing, the protein was removed by centrifugation at 14, g room temperature for 5 min.
Chromatogram of plasma containing caffeine and IS is presented in Figure 1. Plasma concentrations of caffeine were determined by interpolating the peak height ratios of caffeine and IS versus respective caffeine concentrations 0. Chromatogram of plasma sample containing 4. The lower limit of quantification LLOQ was 0.